Maggie made a good point in a previous post.
It really stings when you screw up your courage and send off a manuscript to someone whom you respect, someone you'd like to work with (editor or agent). Then the rejection comes in and you wonder, "Why the hell did I bother with this?"
It doesn't bother me that much any more. I'm beginning to think that it doesn't matter. I think I've found my niche.
Have you thought about your niche? If you're published, do you feel comfortable in your place? And if you're not, have you thought about where your niche will be (and it can't be 'The New York Times best seller list').